Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors

被引：177

作者：

Ostrowski, Alexis D. ^{[1
]}

Ford, Peter C. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

DALTON TRANSACTIONS | 2009年 / 48期

基金：

美国国家科学基金会;

关键词：

ROUSSINS RED SALT; RUTHENIUM NITROSYL COMPLEX; ISOLATED TAIL ARTERY; VISIBLE-LIGHT; 2-PHOTON EXCITATION; BIOLOGICAL TARGETS; FLASH-PHOTOLYSIS; BLACK SALT; NO DONORS; NANOPARTICLE ASSEMBLIES;

D O I：

10.1039/b912898k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a gamma-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing methods for NO delivery to specific physiological targets. In this Perspective, we describe ongoing investigations focused on photochemical methodologies to deliver therapeutic doses of NO to such targets utilizing transition metal complexes that are nitric oxide precursors. The photochemical strategy has the advantages that it allows for precise control of the timing, location, and dosage for the targeted delivery of a bioactive agent.

引用

页码：10660 / 10669

页数：10

共 91 条

[81] Toward development of water soluble dye derivatized nitrosyl compounds for photochemical delivery of NO [J].

Wecksler, SR ;

Hutchinson, J ;

Ford, PC .

INORGANIC CHEMISTRY, 2006, 45 (03) :1192-1200

[82] A two-photon antenna for photochemical delivery of nitric oxide from a water-soluble, dye-derivatized iron nitrosyl complex using NIR light [J].

Wecksler, SR ;

Mikhailovsky, A ;

Korystov, D ;

Ford, PC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (11) :3831-3837

[83] Single- and two-photon properties of a dye-derivatized Roussin's red salt ester (Fe2(μ-RS)2(NO)4) with a large TPA cross section [J].

Wecksler, Stephen R. ;

Mikhailovsky, Alexander ;

Korystov, Dmitry ;

Buller, Fabian ;

Kannan, Ramamurthi ;

Tan, Loon-Seng ;

Ford, Peter C. .

INORGANIC CHEMISTRY, 2007, 46 (02) :395-402

[84] The multifaceted roles of nitric oxide in cancer [J].

Wink, DA ;

Vodovotz, Y ;

Laval, J ;

Laval, F ;

Dewhirst, MW ;

Mitchell, JB .

CARCINOGENESIS, 1998, 19 (05) :711-721

[85] Nitric oxide and cancer: An introduction [J].

Wink, DA ;

Mitchell, JB .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 34 (08) :951-954

[86] Photochemical nitric oxide precursors: Synthesis, photochemistry, and ligand substitution kinetics of ruthenium salen nitrosyl and ruthenium salophen nitrosyl complexes [J].

Works, CF ;

Jocher, CJ ;

Bart, GD ;

Bu, XH ;

Ford, PC .

INORGANIC CHEMISTRY, 2002, 41 (14) :3728-3739

[87] Photoreactivity of the ruthenium nitrosyl complex, Ru(salen)(Cl)(NO).: Solvent effects on the back reaction of NO with the Lewis acid RuIII(salen)(Cl) [J].

Works, CF ;

Ford, PC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (31) :7592-7593

[88] Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency [J].

Xie, KP ;

Huang, S .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 34 (08) :969-986

[89] PHOTOCHEMICAL FORMATION OF OXOCHROMIUM(IV) TETRAPHENYLPORPHYRIN FROM NITRITOCHROMIUM(III) TETRAPHENYLPORPHYRIN IN BENZENE [J].

YAMAJI, M ;

HAMA, Y ;

MIYAZAKI, Y ;

HOSHINO, M .

INORGANIC CHEMISTRY, 1992, 31 (05) :932-934

[90] Solid tumor physiology and hypoxia-induced chemo/radio-resistance: Novel strategy for cancer therapy: Nitric oxide donor as a therapeutic enhancer [J].

Yasuda, Hiroyasu .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2008, 19 (02) :205-216

← 1 2 3 4 5 6 7 8 9 10 →