Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors

被引：177

作者：

Ostrowski, Alexis D. ^{[1
]}

Ford, Peter C. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

DALTON TRANSACTIONS | 2009年 / 48期

基金：

美国国家科学基金会;

关键词：

ROUSSINS RED SALT; RUTHENIUM NITROSYL COMPLEX; ISOLATED TAIL ARTERY; VISIBLE-LIGHT; 2-PHOTON EXCITATION; BIOLOGICAL TARGETS; FLASH-PHOTOLYSIS; BLACK SALT; NO DONORS; NANOPARTICLE ASSEMBLIES;

D O I：

10.1039/b912898k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a gamma-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing methods for NO delivery to specific physiological targets. In this Perspective, we describe ongoing investigations focused on photochemical methodologies to deliver therapeutic doses of NO to such targets utilizing transition metal complexes that are nitric oxide precursors. The photochemical strategy has the advantages that it allows for precise control of the timing, location, and dosage for the targeted delivery of a bioactive agent.

引用

页码：10660 / 10669

页数：10

共 91 条

[51] Multiphoton microscopy in life sciences [J].

König, K .

JOURNAL OF MICROSCOPY, 2000, 200 (02) :83-104

[52] In situ nitric oxide (NO) measurement by modified electrodes: NO labilized by photolysis of metal nitrosyl complexes [J].

Kudo, S ;

Bourassa, JL ;

Boggs, SE ;

Sato, Y ;

Ford, PC .

ANALYTICAL BIOCHEMISTRY, 1997, 247 (02) :193-202

[53]

Larson DR, 2003, SCIENCE, V300, P1434, DOI 10.1126/science.1083780

[54] Flash photolysis studies of the ruthenium(II) porphyrins Ru(P)(NO)(ONO). Multiple pathways involving reactions of intermediates with nitric oxide [J].

Lorkovic, IM ;

Miranda, KM ;

Lee, B ;

Bernhard, S ;

Schoonover, JR ;

Ford, PC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (45) :11674-11683

[55] Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application [J].

Maranho, Daniela Silva ;

de Lima, Renata Galvao ;

Primo, Fernando Lucas ;

da Silva, Roberto Santana ;

Tedesco, Antonio Claudio .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2009, 85 (03) :705-713

[56]

Miranda K.M., 2000, NITRIC OXIDE-BIOL CH, P41

[57]

MITCHELL JB, 1993, CANCER RES, V53, P5845

[58] Light-activated transfer of nitric oxide from a porous material [J].

Mitchell-Koch, JT ;

Reed, TM ;

Borovik, AS .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (21) :2806-2809

[59] Nitric Oxide: Cancer Target or Anticancer Agent? [J].

Mocellin, Simone .

CURRENT CANCER DRUG TARGETS, 2009, 9 (02) :214-236

[60] Quantum dot fluorescence quenching pathways with Cr(III) complexes.: Photosensitized NO production from trans-Cr(cyclam)(ONO)2+ [J].

Neuman, Daniel ;

Ostrowski, Alexis D. ;

Mikhailovsky, Alexander A. ;

Absalonson, Ryan O. ;

Strouse, Geoffrey F. ;

Ford, Peter C. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (01) :168-175

← 1 2 3 4 5 6 7 8 9 10 →