Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application

被引：41

作者：

Maranho, Daniela Silva ^{[1
]}

de Lima, Renata Galvao ^{[1
]}

Primo, Fernando Lucas ^{[2
]}

da Silva, Roberto Santana ^{[2
]}

Tedesco, Antonio Claudio ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Lab Fotobiol & Fotomed, BR-14040901 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2009年 / 85卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

VISIBLE-LIGHT IRRADIATION; ZINC-PHTHALOCYANINE; NO RELEASE; PHOTOSENSITIZERS; MECHANISMS; PDT;

D O I：

10.1111/j.1751-1097.2008.00481.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) showed the detection and quantification of nitric oxide (NO) and singlet oxygen (O-1(2)) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.

引用

收藏

页码：705 / 713

页数：9

相关论文

共 45 条

[1] LIPOSOMES WITH PROLONGED CIRCULATION TIMES - FACTORS AFFECTING UPTAKE BY RETICULOENDOTHELIAL AND OTHER TISSUES [J].

ALLEN, TM ;

HANSEN, C ;

RUTLEDGE, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 981 (01) :27-35

[2] A clinical review of PDT for cutaneous malignancies [J].

Allison, Ron R. ;

Sibata, Claudio H. ;

Downie, Gordon H. ;

Cuenca, Rosa E. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2006, 3 (04) :214-226

[3] A macrocyclic nitrosyl ruthenium complex is a NO donor that induces rat aorta relaxation [J].

Bonaventura, D ;

Oliveira, FD ;

Togniolo, V ;

Tedesco, AC ;

da Silva, RS ;

Bendhack, LM .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2004, 10 (02) :83-91

[4] Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: Sodium nitroprusside and a new ruthenium complex [J].

Bonaventura, Daniella ;

de Lima, Renata Galvao ;

Vercesi, Juliana A. ;

da Silva, Roberto Santana ;

Bendhack, Lusiane M. .

VASCULAR PHARMACOLOGY, 2007, 46 (03) :215-222

[5] The inducing NO-vasodilation by chemical reduction of coordinated nitrite ion in cis-[Ru(NO2)L(bpy)2]+ complex [J].

da Rocha, Zenis Novais ;

Pereira Marchesi, Mario Sergio ;

Molin, Josiane Cristina ;

Lunardi, Claure N. ;

Miranda, Katrina M. ;

Bendhack, Lusiane Maria ;

Ford, Peter C. ;

da Silva, Roberto Santana .

DALTON TRANSACTIONS, 2008, (32) :4282-4287

[6] Photoinduced electron transfer between the cationic complexes Ru(NH3)5pz2+ and trans-RuCl([15]aneN4)NO2+ mediated by phosphate ion:: Visible light generation of nitric oxide for biological targets [J].

da Silva, Roberto S. ;

Marchesi, Mario S. P. ;

Khin, Chosu ;

Lunardi, Claure N. ;

Bendhack, Lusiane M. ;

Ford, Peter C. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2007, 111 (24) :6962-6968

[7] Controlled nitric oxide photo-release from nitro ruthenium complexes: The vasodilator response produced by UV light irradiation [J].

de Lima, RG ;

Sauaia, MG ;

Bonaventura, D ;

Tedesco, AC ;

Lopez, RFV ;

Bendhack, LM ;

da Silva, RS .

INORGANICA CHIMICA ACTA, 2005, 358 (09) :2643-2650

[8]

DEMAS JN, 1971, J PHYS CHEM-US, V75, P991, DOI 10.1021/j100678a001

[9] Sensitivity to ALA-PDT of cell lines with different nitric oxide production and resistance to NO cytotoxicity [J].

Di Venosa, G ;

Perotti, C ;

Fukuda, H ;

Batlle, A ;

Casas, A .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2005, 80 (03) :195-202

[10] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

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