Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application

被引：41

作者：

Maranho, Daniela Silva ^{[1
]}

de Lima, Renata Galvao ^{[1
]}

Primo, Fernando Lucas ^{[2
]}

da Silva, Roberto Santana ^{[2
]}

Tedesco, Antonio Claudio ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Lab Fotobiol & Fotomed, BR-14040901 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2009年 / 85卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

VISIBLE-LIGHT IRRADIATION; ZINC-PHTHALOCYANINE; NO RELEASE; PHOTOSENSITIZERS; MECHANISMS; PDT;

D O I：

10.1111/j.1751-1097.2008.00481.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) showed the detection and quantification of nitric oxide (NO) and singlet oxygen (O-1(2)) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.

引用

页码：705 / 713

页数：9

共 45 条

[21] Reactivity of trans-[Ru(NH3)4P(OEt)3NO]X3 (X = PF6-, CF3COO-):: modulation of the release of NO by the trans-effect [J].