A Simple Electrochemical Cytosensor Array for Dynamic Analysis of Carcinoma Cell Surface Glycans

被引：80

作者：

Cheng, Wei ^{[1
,2
]}

Ding, Lin ^{[1
]}

Ding, Shijia ^{[2
]}

Yin, Yibing ^{[2
]}

Ju, Huangxian ^{[1
]}

机构：

[1] Nanjing Univ, Key Lab Analyt Chem Life Sci, Minist Educ China, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China

[2] Chongqing Med Univ, Dept Lab Med, Key Lab Lab Med Diagnost, Minist Educ China, Chongqing 400016, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 35期

基金：

中国国家自然科学基金;

关键词：

biosensors; cancer cells; electrochemistry; glycomics; glycosylation; TUMOR-METASTASIS; K562; CELLS; MEMBRANE; DIFFERENTIATION; GLYCOSYLATION; CARBOHYDRATE; EXPRESSION; GLYCOMICS; CANCER; OLIGOSACCHARIDES;

D O I：

10.1002/anie.200902356

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sugar and spice: The title method for the simultaneous multiplex analysis of intact cell-surface glycans (see picture) shows excellent performance in sensitivity, stability, and practicality. The strategy can be used to analyze the dynamic variation of the cell-surface glycome and to decipher cellular pathophysiological processes. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6465 / 6468

页数：4