A Simple Electrochemical Cytosensor Array for Dynamic Analysis of Carcinoma Cell Surface Glycans

被引：80

作者：

Cheng, Wei ^{[1
,2
]}

Ding, Lin ^{[1
]}

Ding, Shijia ^{[2
]}

Yin, Yibing ^{[2
]}

Ju, Huangxian ^{[1
]}

机构：

[1] Nanjing Univ, Key Lab Analyt Chem Life Sci, Minist Educ China, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China

[2] Chongqing Med Univ, Dept Lab Med, Key Lab Lab Med Diagnost, Minist Educ China, Chongqing 400016, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 35期

基金：

中国国家自然科学基金;

关键词：

biosensors; cancer cells; electrochemistry; glycomics; glycosylation; TUMOR-METASTASIS; K562; CELLS; MEMBRANE; DIFFERENTIATION; GLYCOSYLATION; CARBOHYDRATE; EXPRESSION; GLYCOMICS; CANCER; OLIGOSACCHARIDES;

D O I：

10.1002/anie.200902356

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sugar and spice: The title method for the simultaneous multiplex analysis of intact cell-surface glycans (see picture) shows excellent performance in sensitivity, stability, and practicality. The strategy can be used to analyze the dynamic variation of the cell-surface glycome and to decipher cellular pathophysiological processes. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

收藏

页码：6465 / 6468

页数：4

相关论文

共 32 条

[21] Assessing the terminal glycosylation of a glycoprotein by the naked eye [J].

Sorensen, Mads D. ;

Martins, Rita ;

Hindsgaul, Ole .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (14) :2403-2407

[22] Chip based electroanalytical systems for cell analysis [J].

Spegel, Christer ;

Heiskanen, Arto ;

Skjolding, Lars Henrik Daehli ;

Emneus, Jenny .

ELECTROANALYSIS, 2008, 20 (06) :680-702

[23] Move over proteomics, here comes glycomics [J].

Srivastava, Sudhir .

JOURNAL OF PROTEOME RESEARCH, 2008, 7 (05) :1799-1799

[24]

Steet RA, 2000, J BIOL CHEM, V275, P26812

[25] Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers [J].

Tao, Sheng-Ce ;

Li, Yu ;

Zhou, Jiangbing ;

Qian, Jiang ;

Schnaar, Ronald L. ;

Zhang, Ying ;

Goldstein, Irwin J. ;

Zhu, Heng ;

Schneck, Jonathan P. .

GLYCOBIOLOGY, 2008, 18 (10) :761-769

[26] A novel strategy for mammalian cell surface glycome profiling using lectin microarray [J].

Tateno, Hiroaki ;

Uchiyama, Noboru ;

Kuno, Atsushi ;

Togayachi, Akira ;

Sato, Takashi ;

Narimatsu, Hisashi ;

Hirabayashi, Jun .

GLYCOBIOLOGY, 2007, 17 (10) :1138-1146

[27] Emerging glycomics technologies [J].

Turnbull, Jeremy E. ;

Field, Robert A. .

NATURE CHEMICAL BIOLOGY, 2007, 3 (02) :74-77

[28] Glycoproteomics and glycomics investigation of membrane N-glycosylproteins from human colon carcinoma cells [J].

Vercoutter-Edouart, Anne-Sophie ;

Slomianny, Marie-Christine ;

Dekeyzer-Beseme, Olivia ;

Haeuw, Jean-Francois ;

Michalski, Jean-Claude .

PROTEOMICS, 2008, 8 (16) :3236-3256

[29] Use of lectins for probing differentiated human embryonic stem cells for carbohydrates [J].

Wearne, Kimberly A. ;

Winter, Harry C. ;

O'Shea, Katherine ;

Goldstein, Irwin J. .

GLYCOBIOLOGY, 2006, 16 (10) :981-990

[30] Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways [J].

Witt, O ;

Sand, K ;

Pekrun, A .

BLOOD, 2000, 95 (07) :2391-2396

← 1 2 3 4 →