NMR in drug discovery

被引：332

作者：

Pellecchia, M

Sem, DS

Wüthrich, K

机构：

[1] TRIAD Therapeut Inc, San Diego, CA 92121 USA

[2] Scripps Res Inst, La Jolla, CA 92037 USA

[3] Swiss Fed Inst Technol, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 03期

关键词：

D O I：

10.1038/nrd748

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

NMR spectroscopy has evolved into an important technique in support of structure-based drug design. Here, we survey the principles that enable NMR to provide information on the nature of molecular interactions and, on this basis, we discuss current NMR-based strategies that can identify weak-binding compounds and aid their development into potent, drug-like inhibitors for use as lead compounds in drug discovery.

引用

页码：211 / 219

页数：9

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