Damage of erythrocyte by phenoxyacetic herbicides and their metabolites

被引：56

作者：

Duchnowicz, P ^{[1
]}

Koter, M ^{[1
]}

Duda, W ^{[1
]}

机构：

[1] Univ Lodz, Dept Biophys & Environm Pollut, PL-90237 Lodz, Poland

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 2002年 / 74卷 / 01期

关键词：

D O I：

10.1016/S0048-3575(02)00139-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular background of toxic properties of phenoxy herbicides for humand and animals is insufficiently studied. In this study, damage parameters (hemolysis, hemoglobin oxidation, and lipid peroxidation) were measured in human erythrocytes exposed to several commonly used herbicides from this group (2,4-D, 2,4,5-T, and MCPA) and their phenolic metabolites. For all parameters studied the impact of herbicide metabolites was stronger than that of herbicides themselves. The extent of hemolysis was dose-dependent and also depended on the solvent used. Whereas compounds with methyl groups were more potent in the methemoglobin formation assay, compounds with chlorine substituents caused higher lipid peroxidation. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：1 / 7

页数：7

共 25 条

[1] Mechanisms of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: A review [J].

Bradberry, SM ;

Watt, BE ;

Proudfoot, AT ;

Vale, JA .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2000, 38 (02) :111-122

[2]

Bukowska B, 1998, BIOCHEM MOL BIOL INT, V45, P47

[3] Catalase activity in human erythrocytes: Effect of phenoxyherbicides and their metabolites [J].

Bukowska, B ;

Chajdys, A ;

Duda, W ;

Duchnowiz, P .

CELL BIOLOGY INTERNATIONAL, 2000, 24 (10) :705-711

[4]

CHIU D, 1989, SEMIN HEMATOL, V26, P257

[5]

CORK DJ, 1991, ADV APPL MICROBIOL, V36, P1

[6]

DRABKIN DL, 1946, J BIOL CHEM, V164, P703

[7] Oxidative stress in erythrocytes [J].

Edwards, CJ ;

Fuller, J .

COMPARATIVE HAEMATOLOGY INTERNATIONAL, 1996, 6 (01) :24-31

[8] Quantitative analysis for the enhancement of hydroxyl radical generation by phenols during ozonation of water [J].

Han, SK ;

Ichikawa, K ;

Utsumi, H .

WATER RESEARCH, 1998, 32 (11) :3261-3266

[9] Lambda beta 25-35 induces rapid lysis of red blood cells: contrast with Lambda beta 1-42 and examination of underlying mechanisms [J].

Mattson, MP ;

Begley, JG ;

Mark, RJ ;

Furukawa, K .

BRAIN RESEARCH, 1997, 771 (01) :147-153

[10] DIOXIN AND HEALTH - AGENT ORANGE STUDY BLASTED [J].

MCGOURTY, C .

NATURE, 1989, 340 (6230) :179-179

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