Functional DNA nanotechnology: emerging applications of DNAzymes and aptamers

被引:238
作者
Lu, Yi [1 ]
Liu, Juewen [1 ]
机构
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Chem, Urbana, IL 61801 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/j.copbio.2006.10.004
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In the past 25 years, DNA molecules have been utilized both as powerful synthetic building blocks to create nanoscale architectures and as versatile programmable templates for assembly of nanomaterials. In parallel, the functions of DNA molecules have been expanded from pure genetic information storage to catalytic functions like those of protein enzymes (DNAzymes) and specific binding functions like antibodies (aptamers). In the past few years, a new interdisciplinary field has emerged that aims to combine functional DNA biology with nanotechnology to generate more dynamic and controllable DNA-based nanostructures or DNA-templated nanomaterials that are responsive to chemical stimuli.
引用
收藏
页码:580 / 588
页数:9
相关论文
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