Structure of bis(2-acetylpyridine 3-hexamethyleneiminylthiosemicarbazonato) palladium(II), a potential antitumor complex

被引：43

作者：

Kovala-Demertzi, D ^{[1
]}

Demertzis, MA

Miller, JR

Frampton, CS

Jasinski, JP

West, DX

机构：

[1] Univ Ioannina, Dept Chem, GR-45110 Ioannina, Greece

[2] Univ Essex, Dept Biol & Chem Sci, Colchester CO4 3SQ, Essex, England

[3] Roche Discovery Welwyn, Welwyn Garden City AL7 3AY, Herts, England

[4] Keene State Coll, Dept Chem, Keene, NH 03435 USA

[5] Univ Washington, Dept Chem 351700, Seattle, WA 98195 USA

[6] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 92卷 / 02期

关键词：

palladium(II) complexes; thiosemicarbazonato complexes; crystal structure; antitumor activity;

D O I：

10.1016/S0162-0134(02)00493-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of the potential antitumor complex bis(2-acetyppyridine 3-hexamethyleneiminylthiosemicarbazonato)palladium(II) has been solved. The palladium(H) atom is in a square planar environment surrounded by two cis nitrogen atoms and two cis sulfur atoms. The ligands are not equivalent, one being tridentate with (N,N,S) donation, the other being monodentate using only the sulfur atom to coordinate to the metal. The tridentate ligand shows a Z, E, Z configuration while the monodentate ligand shows an E, E, Z. Intermolecular hydrogen bonds stabilize the structure, while the crystal packing is determined by Pd-C, Pd-pi, C-H-pi and pi-pi interactions. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：137 / 140

页数：4

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