Cutting edge: Distinct NK receptor profiles are imprinted on CD8 T cells in the mucosa and periphery during the same antigen challenge: Role of tissue-specific factors

被引:23
作者
Laouar, Amale
Manocha, Monika
Wan, Meimei
Yagita, Hideo
van Lier, Rene A. W.
Manjunath, N.
机构
[1] CBR Inst Biomed Res, Boston, MA 02115 USA
[2] Harvard Univ, Dept Pediat, Sch Med, Cambridge, MA 02115 USA
[3] Juntendo Univ, Sch Med, Tokyo 113, Japan
[4] Acad Med Ctr, Amsterdam, Netherlands
关键词
D O I
10.4049/jimmunol.178.2.652
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
NK cell receptors (NKRs) modulate T lymphocyte responses by modifying the Ag activation threshold. However, what governs their expression on T cells remains unclear. In this study we show that different NKRs are imprinted on CD8 T cells in the gut mucosa and periphery during the same Ag challenge. After a viral, bacterial, and tumor challenge, most CD8 peritoneal exudate lymphocytes expressed NKG2A but not 2B4. In contrast, most CD8 intraepithelial lymphocytes exhibited 2B4 but not NKG2A. Our data suggest that tissue-specific factors may determine the pattern of NKR expression. In the gut, CD70 licensing appears to promote 2B4 induction on mucosal CD8 T cells. Conversely, retinoic acid produced by the intestinal dendritic cells may suppress NKG2A expression. Thus, tissue-specific factors regulate NKR expression and may confer T cells with differing effector functions in a tissue and site-specific manner.
引用
收藏
页码:652 / 656
页数:5
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