Uniform-sized molecularly imprinted polymer material for (S)-propranolol

被引:50
作者
Haginaka, J [1 ]
Sakai, Y [1 ]
机构
[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
关键词
molecularly imprinted polymer; chiral resolution; propranolol; beta-adrenergic antagonist;
D O I
10.1016/S0731-7085(00)00293-4
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A uniform-sized molecularly imprinted polymer for (S)-propranolol has been prepared by a multi-step swelling and thermal polymerization method using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EDMA) as a host functional monomer and cross-linker: respectively. The obtained (S)-propranolol imprinted MAA-EDMA materials were evaluated using aqueous-rich eluents by HPLC. The (S)-propranolol imprinted MAA-EDMA materials had specific recognition for (S)-propranolol and moderate recognition for some structurally related beta-adrenergic antagonists (especially, pindolol and alprenolol), but had no recognition for other basic compounds, and neutral and acidic compounds. Enantioseparations of propranolol and some structurally related S-adrenergic antagonists were attained with the imprinted MAA-EDMA materials. Hydrophobic interaction of the naphthyloxy and isopropyl groups of propranolol, and ionic interaction of the isopropylamino group of propranolol with the (S)-propranolol imprinted MAA-EDMA materials could play an important role in enantioselective recognition of propranolol. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
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页码:899 / 907
页数:9
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