Palladium-catalyzed cyanation reactions of aryl chlorides

被引：143

作者：

Jin, FQ ^{[1
]}

Confalone, PN ^{[1
]}

机构：

[1] Dupont Merck Pharmaceut Co, Expt Stn, Chem Proc R&D, Wilmington, DE 19880 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

aryl chlorides; cyanation; palladium;

D O I：

10.1016/S0040-4039(00)00384-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have discovered an efficient cyanation of aryl chlorides which employs Pd-2(dba)(3), dppf and Zn as the catalyst and Zn(CN)(2) as the cyanide source. Both electron-deficient and electron-rich aryl chlorides are effectively cyanated under these conditions. This discovery represents the first successful palladium-catalyzed cyanation of both electron-deficient and electron-rich aryl chlorides. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3271 / 3273

页数：3

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