Clinical severity of Alzheimer's disease is associated with PIB uptake in PET

被引：69

作者：

Grimmer, Timo ^{[1
]}

Henriksen, Gjermund ^{[2
]}

Wester, Hans-Juergen ^{[2
]}

Foerstl, Hans

Klunk, William E. ^{[3
]}

Mathis, Chester A. ^{[4
]}

Kurz, Alexander

Drzezga, Alexander ^{[2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Klin & Poliklin Psychiat & Psychotherapie, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Nucl Med, D-81675 Munich, Germany

[3] Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15213 USA

来源：

NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 12期

关键词：

Alzheimer's disease; Dementia; Clinical Dementia Rating; Amyloid plaques; Positron emission tomography; Imaging; 18F]FDG; 11C]PIB; Pittsburgh Compound B; CEREBRAL GLUCOSE-METABOLISM; PITTSBURGH COMPOUND-B; AMYLOID DEPOSITION; DEMENTIA; PLAQUES; BRAIN; AD; NEUROPATHOLOGY; DIAGNOSIS; CRITERIA;

D O I：

10.1016/j.neurobiolaging.2008.01.016

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: The positron emission tomography (PET) tracer [11C]-Pittsburgh Compound-B ([11C]PIB) allows the in vivo assessment of amyloid plaque burden in the brain. In a cross-sectional study we examined the association between the seventy of dementia assessed using the Clinical Dementia Rating scale sum of boxes (CDR-SOB) and [11C]PIB-PET in patients with Alzheimer's disease (AD). Methods: Patients with probable AD who had an AD-typical [18F]FDG-PET scan were included Linear regression analysis in anatomically defined regions-of-interest (ROIs) and correlation analysis using statistical parametric mapping (SPM) were used to determine the association between CDR-SOB and [11C]PIB uptake. Results: The linear regression analyses showed that the CDR-SOB explained approximately 11-22% of the variance of [11C]PIB uptake. The association attained statistical significance in both frontal, in both anterior cingulate cortices, and in both putamina. The SPM analysis showed a significant association in more widespread regions of the brain, with maxima located in similar areas as in the ROI-analysis. Conclusion: The CDR-SOB score is significantly associated with [11C]PIB uptake in patients with AD Thus [11C]PIB is a potential surrogate marker of dementia severity. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1902 / 1909

页数：8

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