Functions of tetramer-stained HIV-specific CD4+ and CD8+ T cells

被引：17

作者：

Kelleher, AD ^{[1
]}

Rowland-Jones, SL ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00102-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HIV infection. Human class II tetramers have been synthesised but their role in defining CD4(+) T cell function in HN infection remains to be determined.

引用

页码：370 / 374

页数：5

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