Functions of tetramer-stained HIV-specific CD4+ and CD8+ T cells

被引：17

作者：

Kelleher, AD ^{[1
]}

Rowland-Jones, SL ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00102-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HIV infection. Human class II tetramers have been synthesised but their role in defining CD4(+) T cell function in HN infection remains to be determined.

引用

页码：370 / 374

页数：5

共 43 条

[31] Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents [J].

Poon, B ;

Grovit-Ferbas, K ;

Stewart, SA ;

Chen, ISY .

SCIENCE, 1998, 281 (5374) :266-269

[32] Vigorous HIV-1-specific CD4(+) T cell responses associated with control of viremia [J].

Rosenberg, ES ;

Billingsley, JM ;

Caliendo, AM ;

Boswell, SL ;

Sax, PE ;

Kalams, SA ;

Walker, BD .

SCIENCE, 1997, 278 (5342) :1447-1450

[33] Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I peptide tetramer [J].

Seth, A ;

Ourmanov, I ;

Kuroda, MJ ;

Schmitz, JE ;

Carroll, MW ;

Wyatt, LS ;

Moss, B ;

Forman, MA ;

Hirsch, VM ;

Letvin, NL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10112-10116

[34] In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes [J].

Speiser, DE ;

Pittet, MJ ;

Valmori, D ;

Dunbar, R ;

Rimoldi, D ;

Liénard, D ;

MacDonald, HR ;

Cerottini, JC ;

Cerundolo, V ;

Romero, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (06) :775-782

[35] Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells [J].

Stewart, SA ;

Poon, B ;

Jowett, JBM ;

Xie, YM ;

Chen, ISY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :12039-12043

[36]

Strebel K, 1999, AIDS, V13, pS13

[37]

Tan LC, 1999, J IMMUNOL, V162, P1827

[38] Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome [J].

Tan, RS ;

Xu, XN ;

Ogg, GS ;

Hansasuta, P ;

Dong, T ;

Rostron, T ;

Luzzi, G ;

Conlon, CP ;

Screaton, GR ;

McMichael, AJ ;

Rowland-Jones, S .

BLOOD, 1999, 93 (05) :1506-1510

[39]

Whelan JA, 1999, J IMMUNOL, V163, P4342

[40] Oligoclonal expansions of CD8+ T cells in chronic HIV infection are antigen specific [J].

Wilson, JDK ;

Ogg, GS ;

Allen, RL ;

Goulder, PJR ;

Kelleher, A ;

Sewell, AK ;

O'Callaghan, CA ;

Rowland-Jones, SL ;

Callan, MFC ;

McMichael, AJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (04) :785-790

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