Synthesis of novel chiral benzophospholanes and their application in asymmetric hydrogenation

被引：55

作者：

Shimizu, H ^{[1
]}

Saito, T ^{[1
]}

Kumobayashi, H ^{[1
]}

机构：

[1] Takasago Int Corp, Cent Res Lab, Hiratsuka, Kanagawa 2540073, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 1-2期

关键词：

asymmetric catalysis; homogeneous catalysis; hydrogenation; P-ligands; rhodium;

D O I：

10.1002/adsc.200390009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new class of chiral ligands bearing one or two benzophospholanes was developed for the purpose of Ru-catalyzed asymmetric hydrogenation. Although results of the Ru catalysis remain insufficient so far, 1,2-bis(2-isopropyl-2,3-dihydro-1H-phosphindol-1-yl)benzene (iPr-BeePHOS: 2b) has been found to provide high enantioselectivity in the Rh-catalyzed asymmetric hydrogenation of an en- amide.

引用

页码：185 / 189

页数：5

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