Two-step potentially prebiotic synthesis of α-D-cytidine-5′-phosphate from D-glyceraldehyde-3-phosphate

被引：29

作者：

Anastasi, Carole ^{[1
]}

Crowe, Michael A. ^{[1
]}

Sutherland, John D. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ja066495v

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

5-Ribonucleotide precursors of RNA have previously been difficult to synthesize under prebiotically plausible conditions because of the inaccessibility of ribose-5-phosphate. Here we demonstrate a process in which ribose-5-phosphate is bypassed, and a cytidine 5-ribonucleotide is efficiently assembled under mild conditions in two steps from glyceraldehyde-3-phosphate, 2-aminooxazole, cyanoacetylene, and water. Copyright © 2006 American Chemical Society.

引用

页码：24 / 25

页数：2

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