Solid-phase organic reactions .2. A review of the literature Nov 95 Nov 96.

被引:439
作者
Hermkens, PHH [1 ]
Ottenheijm, HCJ [1 ]
Rees, DC [1 ]
机构
[1] ORGANON LABS,SCI DEV GRP,NEWHOUSE ML1 5SH,SCOTLAND
关键词
D O I
10.1016/S0040-4020(97)00279-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This Report reviews literature published Nov 1995-Nov 1996 and summarises organic reactions performed on solid-supports. The reactions are presented in a graphical abstract format and examples of amide formation, aromatic nucleophilic substitution, cleavage, condensation, cycloaddition, deprotection, Grignard, heterocycle formation, immobilisation to resin, Michael addition, miscellaneous, multiple component condensation, olefin formation, oxidation, reduction and substitution (nucleophilic/electrophilic) are given. The review is designed as an update to Tetrahedron Report no. 394. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:5643 / 5678
页数:36
相关论文
共 129 条
[21]   Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization cleavage step [J].
Dressman, BA ;
Spangle, LA ;
Kaldor, SW .
TETRAHEDRON LETTERS, 1996, 37 (07) :937-940
[22]   Synthesis and properties of combinatorial libraries of phosphoramidates [J].
Fathi, R ;
Rudolph, MJ ;
Gentles, RG ;
Patel, R ;
MacMillan, EW ;
Reitman, MS ;
Pelham, D ;
Cook, AF .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (16) :5600-5609
[23]  
Fenniri H, 1996, CURR MED CHEM, V3, P343
[24]   Bis-allylic templates for Pd(0)-catalyzed solid phase synthesis of tertiary amines [J].
Flegelova, Z ;
Patek, M .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (19) :6735-6738
[25]   A method for the synthesis of hydroxamic acids on solid phase [J].
Floyd, CD ;
Lewis, CN ;
Patel, SR ;
Whittaker, M .
TETRAHEDRON LETTERS, 1996, 37 (44) :8045-8048
[26]   Use of spin echo magic angle spinning H-1 NMR in reaction monitoring in combinatorial organic synthesis [J].
Garigipati, RS ;
Adams, B ;
Adams, JL ;
Sarkar, SK .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (08) :2911-2914
[27]   The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support [J].
Goff, DA ;
Zuckermann, RN .
TETRAHEDRON LETTERS, 1996, 37 (35) :6247-6250
[28]   Approaches to combinatorial synthesis of heterocycles: A solid-phase synthesis of 1,4-dihydropyridines [J].
Gordeev, MF ;
Patel, DV ;
Gordon, EM .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (03) :924-928
[29]   Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines [J].
Gordeev, MF ;
Patel, DV ;
Wu, J ;
Gordon, EM .
TETRAHEDRON LETTERS, 1996, 37 (27) :4643-4646
[30]   Photoacoustic FTIR spectroscopy, a nondestructive method for sensitive analysis of solid-phase organic chemistry [J].
Gosselin, F ;
DiRenzo, M ;
Ellis, TH ;
Lubell, WD .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) :7980-7981