Analysis of the gene encoding copper/zinc superoxide dismutase homolog in Dictyostelium discoideum

被引：6

作者：

Akaza, Y ^{[1
]}

Tsuji, A ^{[1
]}

Yasukawa, H ^{[1
]}

机构：

[1] Toyama Univ, Fac Engn, Div Bioengn, Toyama 9308555, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 12期

关键词：

Cu/Zn superoxide dismutase (SOD); Dictyostelium discoideum; sodD;

D O I：

10.1248/bpb.25.1528

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

SodD, a Cu/Zn superoxide dismutase in Dictyostelium discoideum, shows 48% identity to the cytosolic Cu/Zn superoxide dismutase (SOD) of Saccharomyces cerevisiae (SOD1). The sodD gene is expressed in D. discoideum cells at late-developmental stages. However, gene expression was not detected in the sporeless mutant, indicating that sodD is a spore cell-specific gene. The D. discoideum mutant, in which sodD was disrupted, grew and formed a multicellular structure normally, therefore the gene is not essential for growth and development. The mutant spores were sensitive to UV-light compared to the wild-type spores, indicating that SodD protects spores from cellular damage caused by UV-light.

引用

页码：1528 / 1532

页数：5

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