Ras effectors and their role in mitogenesis and oncogenesis

被引：149

作者：

Joneson, T ^{[1
]}

BarSagi, D ^{[1
]}

机构：

[1] SUNY STONY BROOK,DEPT MOL GENET & MICROBIOL,STONY BROOK,NY 11794

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1997年 / 75卷 / 08期

关键词：

Ras; Ras effectors; oncogene; mitogenesis; cytoskeleton;

D O I：

10.1007/s001090050143

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pas proteins are membrane-bound GTP-binding proteins that play a critical role in the control of cell growth. Through a large number of genetic and biochemical studies it is becoming increasingly evident that the biological activity of Pas proteins is mediated by multiple signaling pathways. This review provides an account of the target proteins that interact with Pas and the functional consequences of these interactions. The relative contribution of the different Pas effector pathways to the mitogenic and oncogenic effects of Pas are discussed.

引用

页码：587 / 593

页数：7

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