Ras effectors and their role in mitogenesis and oncogenesis

Pas proteins are membrane-bound GTP-binding proteins that play a critical role in the control of cell growth. Through a large number of genetic and biochemical studies it is becoming increasingly evident that the biological activity of Pas proteins is mediated by multiple signaling pathways. This review provides an account of the target proteins that interact with Pas and the functional consequences of these interactions. The relative contribution of the different Pas effector pathways to the mitogenic and oncogenic effects of Pas are discussed.