First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720

被引：26

作者：

Hinterding, K ^{[1
]}

Albert, R ^{[1
]}

Cottens, S ^{[1
]}

机构：

[1] Novartis Pharma AG, Transplantat Res, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 45期

关键词：

immunosuppressant; FTY720; Schoellkopf-auxiliary; phosphates;

D O I：

10.1016/S0040-4039(02)01925-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

FTY720 is an immunosuppressant with a novel mode of action and is highly effective in animal models of transplantation and autoimmunity. Herein we describe the first asymmetric synthesis of chiral FTY720 analogues using the Schollkopf-protocol. We also describe a practical synthesis of the corresponding phosphates, which are essential tools for elucidation of FTY720's mechanism of action. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8095 / 8097

页数：3

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