Cohesin: Its Roles and Mechanisms

被引：753

作者：

Nasmyth, Kim ^{[1
]}

Haering, Christian H. ^{[2
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

[2] European Mol Biol Lab, D-69115 Heidelberg, Germany

来源：

ANNUAL REVIEW OF GENETICS | 2009年 / 43卷

关键词：

chromosome segregation; sister chromatid cohesion; mitosis; meiosis; structural maintenance of chromosomes (Smc); ABC ATPase; SISTER-CHROMATID COHESION; DOUBLE-STRAND BREAKS; DE-LANGE-SYNDROME; SPINDLE-ASSEMBLY CHECKPOINT; ANAPHASE-PROMOTING COMPLEX; PROTEIN PHOSPHATASE 2A; MEIOSIS-I DEPENDS; CHROMOSOME SEGREGATION; S-PHASE; ROBERTS-SYNDROME;

D O I：

10.1146/annurev-genet-102108-134233

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

引用

收藏

页码：525 / 558

页数：34

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