An efficient method for the preparation of peptide alcohols

被引：13

作者：

Katritzky, Alan Roy ^{[1
]}

Abo-Dya, Nader Elmaghwry ^{[1
,2
]}

Tala, Srinivasa Rao ^{[1
]}

Gyanda, Kapil ^{[1
]}

Abdel-Samii, Zakaria Kamel ^{[2
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Zagazig Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Zagazig 44519, Egypt

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 21期

关键词：

ASYMMETRIC TRANSFER-HYDROGENATION; AMINO-ACIDS; ALDEHYDES; CONVENIENT; DIPEPTIDES; LIGANDS; FMOC-ALPHA-AMINOACYL)BENZOTRIAZOLES; DERIVATIVES; REDUCTION; ACYLATION;

D O I：

10.1039/b905730g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Protected LL-dipeptide alcohols 3a-p, diastereomeric mixture (3d + 3d') and tripeptide alcohols 6a-c were synthesized by treatment of various amino alcohols with N-protected(alpha-aminoacyl)benzotriazoles 1a-c, 1f-m, (1a + 1a') and N-protected(alpha-dipeptidoyl) benzotriazoles 5a, 5b respectively in good yields with complete retention of chirality.

引用

页码：4444 / 4447

页数：4

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