Synthesis of chiral alpha-substituted beta-hydroxy acid derivatives on solid support

被引：60

作者：

Purandare, AV

Natarajan, S

机构：

[1] Discovery Chemistry, Bristol-Myers Squibb P.R.I., PO Box 4000, Princeton

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(97)10378-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective aldol condensation using solid supported chiral auxiliary was used for the synthesis of alpha-substituted-beta-hydroxy acid and ester. The solid phase synthesis proceeded with high degree of enatioselectivity, as is observed in solution chemistry. (C) 1997 Elsevier Science Ltd.

引用

页码：8777 / 8780

页数：4

共 5 条

[1] The preparation and first application of a polymer-supported ''Evans'' oxazolidinone. [J].

Allin, SM ;

Shuttleworth, SJ .

TETRAHEDRON LETTERS, 1996, 37 (44) :8023-8026

[2] ENANTIOSELECTIVE ALDOL CONDENSATIONS .2. ERYTHRO-SELECTIVE CHIRAL ALOL CONDENSATIONS VIA BORON ENOLATES [J].

EVANS, DA ;

BARTROLI, J ;

SHIH, TL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (08) :2127-2129

[3] LITHIUM-INITIATED IMIDE FORMATION - A SIMPLE METHOD FOR N-ACYLATION OF 2-OXAZOLIDINONES AND BORNANE-2,10-SULTAM [J].

HO, GJ ;

MATHRE, DJ .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (07) :2271-2273

[4] LIBRARY-BASED LEAD COMPOUND DISCOVERY - ANTIOXIDANTS BY AN ANALOGOUS SYNTHESIS DECONVOLUTIVE ASSAY STRATEGY [J].

KURTH, MJ ;

RANDALL, LAA ;

CHEN, CX ;

MELANDER, C ;

MILLER, RB ;

MCALISTER, K ;

REITZ, G ;

KANG, R ;

NAKATSU, T ;

GREEN, C .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (20) :5862-5864

[5] A SURPRISING OBSERVATION ABOUT MITSUNOBU REACTIONS IN SOLID-PHASE SYNTHESIS [J].

RICHTER, LS ;

GADEK, TR .

TETRAHEDRON LETTERS, 1994, 35 (27) :4705-4706

← 1 →