Glucocorticoids and immune function: unknown dimensions and new frontiers

被引：303

作者：

Wilckens, T ^{[1
]}

DeRijk, R ^{[1
]}

机构：

[1] SYLVIUS LAB,DIV MED PHARMACOL,LEIDEN AMSTERDAM CTR DRUG RES,NL-2333 AL LEIDEN,NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(97)01111-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the importance of glucocorticoids (GCs) to modern medicine, the physiological role of endogenous corticosteroids in immunomodulation is poorly understood. This article discusses evidence suggesting that endogenous GCs not only suppress but also direct and enhance immune functions. These often overlooked actions might well be more important than the inhibitory functions during host defence and the maintenance of homeostasis.

引用

页码：418 / 424

页数：7

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