ent-Abietane diterpenoids from Isodon rubescens var. rubescens

被引：32

作者：

Huang, Sheng-Xiong

Pu, Jian-Xin

Xiao, Wei-Lie

Li, Li-Mei

Weng, Zhi-Ying

Zhou, Yan

Han, Quan-Bin

Peng, Shu-Lin

Ding, Li-Sheng

Lou, Li-Guang

Sun, Han-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200032, Peoples R China

来源：

PHYTOCHEMISTRY | 2007年 / 68卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Isodon rubescens var. rubescens; Labiatae; ent-abietane; hebeiabinin; diterpenoid; cytotoxicity;

D O I：

10.1016/j.phytochem.2006.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 mu M against A549 cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：616 / 622

页数：7

共 13 条

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