Roles of aurora kinases in mitosis and tumorigenesis

被引：493

作者：

Fu, Jingyan

Bian, Minglei

Jiang, Qing ^{[1
]}

Zhang, Chuanmao

机构：

[1] Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China

来源：

MOLECULAR CANCER RESEARCH | 2007年 / 5卷 / 01期

关键词：

D O I：

10.1158/1541-7786.MCR-06-0208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis.

引用

页码：1 / 10

页数：10

共 115 条

[11] Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and in a complex inase activity is phosphorylation [J].

Bolton, MA ;

Lan, WJ ;

Powers, SE ;

McCleland, ML ;

Kuang, J ;

Stukenberg, PT .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (09) :3064-3077

[12] APC/Fizzy-Related targets Aurora-A kinase for proteolysis [J].

Castro, A ;

Arlot-Bonnemains, Y ;

Vigneron, S ;

Labbé, JC ;

Prigent, C ;

Lorca, T .

EMBO REPORTS, 2002, 3 (05) :457-462

[13] The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A [J].

Castro, A ;

Vigneron, S ;

Bernis, C ;

Labbé, JC ;

Prigent, C ;

Lorca, T .

EMBO REPORTS, 2002, 3 (12) :1209-1214

[14] CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage [J].

Cazales, M ;

Schmitt, E ;

Montembault, E ;

Dozier, C ;

Prigent, C ;

Ducommun, B .

CELL CYCLE, 2005, 4 (09) :1233-1238

[15]

CHAN CSM, 1993, GENETICS, V135, P677

[16] Crystal structure of aurora-2, an oncogenic serine/threonine kinase [J].

Cheetham, GMT ;

Knegtel, RMA ;

Coll, JT ;

Renwick, SB ;

Swenson, L ;

Weber, P ;

Lippke, JA ;

Austen, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (45) :42419-42422

[17] Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells [J].

Chen, J ;

Jin, S ;

Tahir, SK ;

Zhang, HC ;

Liu, XS ;

Sarthy, AV ;

McGonigal, TP ;

Liu, ZH ;

Rosenberg, SH ;

Ng, SC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (01) :486-490

[18] Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function [J].

Chen, SS ;

Chang, PC ;

Cheng, YW ;

Tang, FM ;

Lin, YS .

EMBO JOURNAL, 2002, 21 (17) :4491-4499

[19] Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? [J].

Clarke, PR ;

Zhang, CM .

TRENDS IN CELL BIOLOGY, 2001, 11 (09) :366-371

[20] Requirements for the destruction of human Aurora-A [J].

Crane, R ;

Kloepfer, A ;

Ruderman, JV .

JOURNAL OF CELL SCIENCE, 2004, 117 (25) :5975-5983

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