Photochemistry on soluble polymer supports: Synthesis of nucleosides

被引：22

作者：

Zhong, JH ^{[1
]}

Fishman, A ^{[1
]}

Lee-Ruff, E ^{[1
]}

机构：

[1] York Univ, Dept Chem, N York, ON M3J 1P3, Canada

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 25期

关键词：

D O I：

10.1021/ol026881r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new soluble polymer support synthesis of nucleosides is described. The photochemical ring expansion of cyclobutanones in the presence of poly(ethylene glycol) (PEG) results in polymer-supported ribosides. These photoadducts can be cleaved from the polymer under VorbrUggen coupling conditions with TMS-protected purines and pyrimidines to give ribonucleosides. The method has been extended to include modified PEGs with dendritic end-groups in order to improve the loading levels for these coupling reactions.

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页码：4415 / 4417

页数：3

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