Preparation of oligonucleotides containing nonnatural base analogs.

被引:2
作者
Eritja, R [1 ]
Adam, V [1 ]
Avino, A [1 ]
Diaz, AR [1 ]
Fabrega, C [1 ]
Ferrer, E [1 ]
Grotli, M [1 ]
Garcia, RG [1 ]
Hoffmann, M [1 ]
Marquez, VE [1 ]
Wiersma, M [1 ]
机构
[1] NCI,NIH,BETHESDA,MD 20892
来源
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 5-6期
关键词
D O I
10.1080/07328319708002936
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The preparation of oligonucleotides containing 5-amino-2'-deoxyuridine, 5-N-acetamido-2'-deoxyuridine, 5-aza-2'-deoxycytidine and N-2-substituted guanosine derivatives is described. In each case selection of the appropriate protective group, synthesis and deprotection conditions is discussed.
引用
收藏
页码:697 / 702
页数:6
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