Gp130 receptor ligands as potential therapeutic targets for obesity

被引：101

作者：

Febbraio, Mark A. ^{[1
]}

机构：

[1] Baker Heart Res Inst, Div Diabet & Metab, Cellular & Mol Metab Lab, Melbourne, Vic 8008, Australia

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 04期

关键词：

D O I：

10.1172/JCI30453

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Obesity and its related cluster of pathophysiologic conditions including insulin resistance, glucose intolerance, dyslipidemia, and hypertension are recognized as growing threats to world health. It is now estimated that 10% of the world's population is overweight or obese. As a result, new therapeutic options for the treatment of obesity are clearly warranted. Recent research has focused on the role that gp130 receptor ligands may play as potential therapeutic targets in obesity. One cytokine in particular, ciliary neurotrophic factor (CNTF), acts both centrally and peripherally and mimics the biologic actions of the appetite control hormone leptin, but unlike leptin, CNTF appears to be effective in obesity and as such may have therapeutic potential. In addition, CNTF suppresses inflammatory signaling cascades associated with lipid accumulation in liver and skeletal muscle. This review examines the potential role of gp130 receptor ligands as part of a therapeutic strategy to treat obesity.

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页码：841 / 849

页数：9

相关论文

共 113 条

[41] Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 [J].

Howard, JK ;

Cave, BJ ;

Oksanen, LJ ;

Tzameli, I ;

Bjorbæk, C ;

Flier, JS .

NATURE MEDICINE, 2004, 10 (07) :734-738

[42]

Irrcher I, 2006, FASEB J, V20, pA389

[43] gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor [J].

Janoschek, Ruth ;

Plum, Leona ;

Koch, Linda ;

Muenzeberg, Heike ;

Diano, Sabrina ;

Shanabrough, Marya ;

Mueller, Werner ;

Horvath, Tamas L. ;

Bruening, Jens C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (28) :10707-10712

[44] AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism [J].

Kahn, BB ;

Alquier, T ;

Carling, D ;

Hardie, DG .

CELL METABOLISM, 2005, 1 (01) :15-25

[45] Receptor recognition sites of cytokines are organized as exchangeable modules -: Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6 [J].

Kallen, KJ ;

Grötzinger, J ;

Lelièvre, E ;

Vollmer, P ;

Aasland, D ;

Renné, C ;

Müllberg, J ;

zum Buschenfelde, KHM ;

Gascan, H ;

Rose-John, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) :11859-11867

[46] Circumventing leptin resistance for weight control [J].

Kalra, SP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4279-4281

[47] Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain [J].

Kelly, JF ;

Elias, CF ;

Lee, CE ;

Ahima, RS ;

Seeley, RJ ;

Bjorbaek, C ;

Oka, T ;

Saper, CB ;

Flier, JS ;

Elmquist, JK .

DIABETES, 2004, 53 (04) :911-920

[48] AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise [J].

Kelly, M ;

Keller, C ;

Avilucea, PR ;

Keller, P ;

Luo, ZJ ;

Xiang, XQ ;

Giralt, M ;

Hidalgo, J ;

Saha, AK ;

Pedersen, BK ;

Ruderman, NB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 320 (02) :449-454

[49] THE ROLE OF DEPOT FAT IN THE HYPOTHALAMIC CONTROL OF FOOD INTAKE IN THE RAT [J].

KENNEDY, GC .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1953, 140 (901) :578-592

[50] Differential effects of interleukin-6 and-10 on skeletal muscle and liver insulin action in vivo [J].

Kim, HJ ;

Higashimori, T ;

Park, SY ;

Choi, H ;

Dong, JY ;

Kim, YJ ;

Noh, HL ;

Cho, YR ;

Cline, G ;

Kim, YB ;

Kim, JK .

DIABETES, 2004, 53 (04) :1060-1067

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