Modification of post-PKS tailoring steps through combinatorial biosynthesis

被引：212

作者：

Rix, U ^{[1
]}

Fischer, C ^{[1
]}

Remsing, LL ^{[1
]}

Rohr, J ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA

来源：

NATURAL PRODUCT REPORTS | 2002年 / 19卷 / 05期

关键词：

D O I：

10.1039/b103920m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases, ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases. Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.

引用

页码：542 / 580

页数：39

共 248 条

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