Modification of post-PKS tailoring steps through combinatorial biosynthesis

被引:212
作者
Rix, U [1 ]
Fischer, C [1 ]
Remsing, LL [1 ]
Rohr, J [1 ]
机构
[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA
关键词
D O I
10.1039/b103920m
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases, ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases. Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.
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页码:542 / 580
页数:39
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