Modification of post-PKS tailoring steps through combinatorial biosynthesis

被引：212

作者：

Rix, U ^{[1
]}

Fischer, C ^{[1
]}

Remsing, LL ^{[1
]}

Rohr, J ^{[1
]}

机构：

[1] Univ Kentucky, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA

来源：

NATURAL PRODUCT REPORTS | 2002年 / 19卷 / 05期

关键词：

D O I：

10.1039/b103920m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases, ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases. Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.

引用

页码：542 / 580

页数：39

共 248 条

[71] New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster
Gaisser, S
Lill, R
Wirtz, G
Grolle, F
Staunton, J
Leadlay, PF
[J]. MOLECULAR MICROBIOLOGY, 2001, 41 (05) : 1223 - 1231
[72] Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome
Gandecha, AR
Large, SL
Cundliffe, E
[J]. GENE, 1997, 184 (02) : 197 - 203
[73] Bovine α1,3-galactosyltransferase catalytic domain structure and its relationship with ABO histo-blood group and glycosphingolipid glycosyltransferases
Gastinel, LN
Bignon, C
Misra, AK
Hindsgaul, O
Shaper, JH
Joziasse, DH
[J]. EMBO JOURNAL, 2001, 20 (04) : 638 - 649
[74] Crystal structures of the bovine β4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
Gastinel, LN
Cambillau, C
Bourne, Y
[J]. EMBO JOURNAL, 1999, 18 (13) : 3546 - 3557
[75] Studies on the biosynthesis of epothilones:: The PKS and epothilone C/D monooxygenase
Gerth, K
Steinmetz, H
Höfle, G
Reichenbach, H
[J]. JOURNAL OF ANTIBIOTICS, 2001, 54 (02) : 144 - 148
[76] The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties
González, A
Remsing, LL
Lombó, F
Fernández, MJ
Prado, L
Braña, AF
Künzel, E
Rohr, J
Méndez, C
Salas, JA
[J]. MOLECULAR AND GENERAL GENETICS, 2001, 264 (06): : 827 - 835
[77] Biosynthesis of 1-deoxy-1-imino-D-erythrose 4-phosphate: A defining metabolite in the aminoshikimate pathway
Guo, JT
Frost, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (04) : 528 - 529
[78] The 1.9 Å crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis
Ha, S
Walker, D
Shi, YG
Walker, S
[J]. PROTEIN SCIENCE, 2000, 9 (06) : 1045 - 1052
[79] Learning nature's strategies for making deoxy sugars: Pathways, mechanisms, and combinatorial applications
Hallis, TM
Liu, HW
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (07) : 579 - 588
[80] A MACROLIDE 3-O-ACYLTRANSFERASE GENE FROM THE MIDECAMYCIN-PRODUCING SPECIES STREPTOMYCES-MYCAROFACIENS
HARA, O
HUTCHINSON, CR
[J]. JOURNAL OF BACTERIOLOGY, 1992, 174 (15) : 5141 - 5144

← 3 4 5 6 7 8 9 10 11 12 →