Stereoselective synthesis of a functionalised bicyclic core of neocarzinostatin and kedarcidin chromophores

被引：36

作者：

Caddick, S

Delisser, VM

机构：

[1] Chemistry Laboratory, Ctr. for Biomol. Des./Drug Devmt., University of Sussex, Falmer

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 13期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)00347-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of a bicyclic ring system related to Neocarzinostatin and Kedarcidin Chromophores is described; key steps involve stereoselective conjugate addition of an enediyne to an enone and intramolecular aldol reaction of a cobalt complexed alkynyl aldehyde. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：2355 / 2358

页数：4

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