Enantio- and chemoselective reduction of 2,4-diketo acid derivatives with cinchona modified Pt-catalyst -: Synthesis of (R)-2-hydroxy-4-phenylbutyric acid ethyl ester

被引：45

作者：

Studer, M ^{[1
]}

Burkhardt, S ^{[1
]}

Indolese, AF ^{[1
]}

Blaser, HU ^{[1
]}

机构：

[1] Solvias AG, CH-4002 Basel, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 14期

关键词：

D O I：

10.1039/b002538k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantio- and chemoselective hydrogenation of several 2,4-diketo acid derivatives to the corresponding 2-hydroxy compounds with cinchona modified Pt catalysts can be carried out with chemoselectivities of > 99% and enantioselectivities up to 86% (R) and 68% (S), respectively, and enrichment to > 98% ee was possible for several compounds by one crystallization, opening up an efficient technical synthesis of (R)-2-hydroxy-4-phenylbutyric acid ethyl ester, a building block for several ACE inhibitors.

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页码：1327 / 1328

页数：2

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