Two-pore domain K+ channels -: molecular sensors

被引：80

作者：

O'Connell, AD ^{[1
]}

Morton, MJ ^{[1
]}

Hunter, M ^{[1
]}

机构：

[1] Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2002年 / 1566卷 / 1-2期

关键词：

potassium; ion channel; pore; pH sensitivity;

D O I：

10.1016/S0005-2736(02)00597-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two-pore domain K+ (K2P) channels have been cloned from a variety of species and tissues, They have been characterised biophysically as a 'background' K+-selective conductance and are gated by pH, stretch, heat, coupling to G-proteins and anaesthetics. Whilst their precise physiological function is unknown, they are likely to represent an increasingly important family of membrane proteins. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：152 / 161

页数：10

共 60 条

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