Salbutamol plastic membrane electrodes based on individual and mixed ion-exchangers of salbutamolium phosphotungstate and phosphomolybdate

Salbutamol (Sl), also known as albuterol, selective PVC membranes based on ion associates of salbutamolium phosphotungstate (Sl-PTA), salbutamolium phosphomolybdate (Sl-PMA) or a mixture of both (Sl-PTA/PMA) were prepared. The electrodes displayed a linear response over the concentration range 6.3 x 10(-6)-1.0 x 10(-1) mol dm(-3) salbutamol sulfate (Sl(2)SO(4)). The working pH ranges of the above electrodes were 2.5-11.0, 3.0-11.0 and 2.5-10.5 and their isothermal temperature coefficients were 0.00095, 0.00105 and 0.00136 V degrees C-1, respectively. The electrodes showed good selectivity to salbutamolium ion with respect to many inorganic cations, sugars and amino acids. The standard additions method was used to determine Sl(2)SO(4) in pure solutions and pharmaceutical preparations with high accuracy and precision.