Total synthesis of saturated and unsaturated di-trans-N-substituted cyclam-based macrocycles through a versatile intermediate

被引：16

作者：

Barros, MT ^{[1
]}

Siñeriz, F ^{[1
]}

机构：

[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, P-2825114 Monte De Caparica, Portugal

来源：

TETRAHEDRON | 2000年 / 56卷 / 27期

关键词：

aza compounds; macrocycles; asymmetry; cyclisation;

D O I：

10.1016/S0040-4020(00)00382-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of di-trans-N-substituted cyclam-type macrocycles through a versatile intermediate is described for the first time. This synthesis uses readily available low-cost commercial reagents. This synthesis was designed in such a way that the products and some intermediates could be selectively deprotected providing versatility both during the synthesis and for the utility of the final product. Thus, it should be possible to form cryptand molecules with trans bridges with good selectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4759 / 4764

页数：6

共 25 条

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