Blood-brain barrier delivery

被引：922

作者：

Pardridge, William M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 1-2期

关键词：

D O I：

10.1016/j.drudis.2006.10.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and > 98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this barrier. Therefore, brain drug development programs of the future need to be re-configured so that drugs are formulated to enable transport into the brain via endogenous BBB transporters.

引用

页码：54 / 61

页数：8

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