Circadian modulation of Fos responses to odor of the red fox, a rodent predator, in the rat olfactory system

被引：66

作者：

Funk, D ^{[1
]}

Amir, S ^{[1
]}

机构：

[1] Concordia Univ, Ctr Studies Behav Neurobiol, Dept Psychol, Montreal, PQ H3G 1M8, Canada

来源：

BRAIN RESEARCH | 2000年 / 866卷 / 1-2期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

olfactory system; predator odor; fox urine; Fos immunocytochemistry; circadian rhythm; rat;

D O I：

10.1016/S0006-8993(00)02249-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously shown that neuronal responses to a biologically neutral odor, cedar wood oil, in the olfactory system are greater in the subjective night compared to subjective day. in the present study, we confirm these results and extend them to a biologically relevant odor, the urine of the red fox, a rodent predator. Fos induced by exposure of rats to fox urine or a neutral odor, mineral oil, was markedly enhanced during the subjective night compared to subjective day in the main olfactory bulb, primary olfactory cortex, and other structures related to olfaction. These results show that neuronal responses to an ethologically relevant odor follow a circadian rhythm similar to biologically neutral odors. Fos responses induced by fox urine were observed to be of greater magnitude than a neutral odor in brain areas involved in fear responses, suggesting that fox urine activates fear circuitry. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：262 / 267

页数：6

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