In vivo binding of [F-18]altanserin to rat brain 5HT(2) receptors: A film and electronic autoradiographic study

被引：19

作者：

Biver, F ^{[1
]}

Lotstra, F ^{[1
]}

Monclus, M ^{[1
]}

Dethy, S ^{[1
]}

Damhaut, P ^{[1
]}

Wikler, D ^{[1
]}

Luxen, A ^{[1
]}

Goldman, S ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS, HOP ERASME, PET BIOMED CYCLOTRON UNIT, B-1070 BRUSSELS, BELGIUM

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1997年 / 24卷 / 04期

关键词：

F-18]altanserin; 5HT(2) receptors; rat; brain; autoradiography; PET;

D O I：

10.1016/S0969-8051(97)00054-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To further validate its use in positron emission tomography (PET), we studied the binding of [F-18]altanserin, a specific 5HT(2) radioligand, in the rat brain using in vivo autoradiography. Distribution of [F-18]altanserin binding was comparable to the in vitro mapping of 5HT(2) receptors reported in the literature. Selective displacers were used to test the reversibility and the selectivity of this radioligand. Specific binding of [F-18]altanserin in the rat frontal cortex was quantified by direct counting with an electronic imaging system and by quantification on digitalized autoradiograms. Close results of about 30 pmol/g were obtained with both methods. Our data confirmed that [F-18]altanserin is a valid tracer for 5HT(2) receptors binding studies. (C) 1997 Elsevier Science Inc.

引用

页码：357 / 360

页数：4

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