Inositol pyrophosphates regulate endocytic trafficking

被引：135

作者：

Saiardi, A

Sciambi, C

McCaffery, JM

Wendland, B

Snyder, SH

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Integrated Imaging Ctr, Baltimore, MD 21218 USA

[5] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 22期

关键词：

D O I：

10.1073/pnas.212527899

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.

引用

页码：14206 / 14211

页数：6

共 36 条

[1] Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p [J].