Angiogenesis in atherogenesis

被引:96
作者
Herrmann, Joerg
Lerman, Lilach O.
Mukhopadhyay, Debabrata
Napoli, Claudio
Lerman, Amir
机构
[1] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA
[2] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA
[3] Mayo Clin, Div Biochem & Mol Biol, Rochester, MN 55905 USA
[4] Univ Naples 2, Dept Gen Pathol, Div Clin Pathol, Naples, Italy
[5] Univ Naples 2, Excellence Res Ctr Cardiovasc Dis, Sch Med 1, Naples, Italy
关键词
atherosclerosis; cancer; neovascularization; oxidative stress; pathology;
D O I
10.1161/01.ATV.0000233387.90257.9b
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinical significance. Of note, this process is associated with neovascularization, and it was not until recently that the implications of angiogenesis in atherogenesis were delineated. This article gives an updated overview on this topic and briefly reflects on the similarities with neovessel formation in carcinogenesis.
引用
收藏
页码:1948 / 1957
页数:10
相关论文
共 126 条
  • [11] Evidence of hypoxic areas within the arterial wall in vivo
    Björnheden, T
    Levin, M
    Evaldsson, M
    Wiklund, O
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (04) : 870 - 876
  • [12] Statin effects beyond lipid lowering-are they clinically relevant?
    Bonetti, PO
    Lerman, LO
    Napoli, C
    Lerman, A
    [J]. EUROPEAN HEART JOURNAL, 2003, 24 (03) : 225 - 248
  • [13] HYPOTHESIS - ISCHEMIC PLAQUE NECROSIS AS THE INITIATOR OF UNSTABLE ANGINA ACUTE MYOCARDIAL-INFARCTION
    BOYD, GW
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1990, 17 (03) : 215 - 218
  • [14] DISTINCT PATTERNS OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN HUMAN ATHEROMA AND NONATHEROSCLEROTIC ARTERIES - ASSOCIATION OF ACIDIC FGF WITH PLAQUE MICROVESSELS AND MACROPHAGES
    BROGI, E
    WINKLES, JA
    UNDERWOOD, R
    CLINTON, SK
    ALBERTS, GF
    LIBBY, P
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (05) : 2408 - 2418
  • [15] IDENTIFICATION OF 92-KD GELATINASE IN HUMAN CORONARY ATHEROSCLEROTIC LESIONS - ASSOCIATION OF ACTIVE ENZYME-SYNTHESIS WITH UNSTABLE ANGINA
    BROWN, DL
    HIBBS, MS
    KEARNEY, M
    LOUSHIN, C
    ISNER, JM
    [J]. CIRCULATION, 1995, 91 (08) : 2125 - 2131
  • [16] Angiogenesis in cancer and other diseases
    Carmeliet, P
    Jain, RK
    [J]. NATURE, 2000, 407 (6801) : 249 - 257
  • [17] Vascular endothelial growth factor enhances atherosclerotic plaque progression
    Celletti, FL
    Waugh, JM
    Amabile, PG
    Brendolan, A
    Hilfiker, PR
    Dake, MD
    [J]. NATURE MEDICINE, 2001, 7 (04) : 425 - 429
  • [18] Inhibition of vascular endothelial growth factor-mediated neointima progression with angiostatin or paclitaxel
    Celletti, FL
    Waugh, JM
    Amabile, PG
    Kao, EY
    Boroumand, S
    Dake, MD
    [J]. JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2002, 13 (07) : 703 - 707
  • [19] Smooth muscle cell proliferation induced by oxidized LDL-borne lysophosphatidyleholine - Evidence for FGF-2 release from cells not extracellular matrix
    Chai, YC
    Binion, DG
    Macklis, R
    Chisolm, GM
    [J]. VASCULAR PHARMACOLOGY, 2002, 38 (04) : 229 - 237
  • [20] Chandler LA, 1999, INT J CANCER, V81, P451, DOI 10.1002/(SICI)1097-0215(19990505)81:3<451::AID-IJC20>3.3.CO