Endolysosomal proteases and their inhibitors in immunity

被引：102

作者：

Bird, Phillip I. ^{[1
]}

Trapani, Joseph A. ^{[2
]}

Villadangos, Jose A. ^{[3
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[2] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia

[3] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 12期

关键词：

INDUCED CELL-DEATH; NF-KAPPA-B; LYSOSOMAL CYSTEINE PROTEASES; TUMOR-NECROSIS-FACTOR; HERPES-SIMPLEX-VIRUS; TOLL-LIKE RECEPTORS; GRANZYME-B; INVARIANT CHAIN; DENDRITIC CELLS; CATHEPSIN-L;

D O I：

10.1038/nri2671

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cellular endolysosomal compartment is dynamic, complex and incompletely understood. Its organelles and constituents vary between different cell types, but endolysosomal proteases are key components of this compartment in all cells. In immune cells, these proteases function in pathogen recognition and elimination, signal processing and cell homeostasis, and they are regulated by dedicated inhibitors. Pathogens can produce analogous proteases to subvert the host immune response. The balance in activity between a protease and its inhibitor can tune the immune response or cause damage as a result of mislocalized proteolysis. In this Review, we highlight recent developments in this area and emphasize the importance of studying the role of endolysosomal proteases, and their natural inhibitors, in the initiation and regulation of immune responses.

引用

页码：871 / 882

页数：12

共 151 条

[81] Toll-like receptors in systemic autoimmune disease [J].

Marshak-Rothstein, Ann .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (11) :823-835

[82] Emerging functions of placental cathepsins [J].

Mason, R. W. .

PLACENTA, 2008, 29 (05) :385-390

[83] Cathepsins are required for toll-like receptor 9 responses [J].

Matsumoto, Fumi ;

Saitoh, Shin-ichiroh ;

Fukui, Ryutaroh ;

Kobayashi, Toshihiko ;

Tammura, Natsuko ;

Konnio, Kazunori ;

Kusumoto, Yutaka ;

Akashi-Takamura, Sachiko ;

Miyake, Kensuke .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 367 (03) :693-699

[84] Proteases in parasitic diseases [J].

McKerrow, James H. ;

Caffrey, Conor ;

Kelly, Ben ;

Loke, P'ng ;

Sajid, Mohammed .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2006, 1 (01) :497-536

[85] Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response [J].

Metkar, Sunil S. ;

Menaa, Cheikh ;

Pardo, Julian ;

Wang, Baikun ;

Wallich, Reinhard ;

Freudenberg, Marina ;

Kim, Stephen ;

Raja, Srikumar M. ;

Shi, Lianfa ;

Simon, Markus M. ;

Froelich, Christopher J. .

IMMUNITY, 2008, 29 (05) :720-733

[86] Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: A possible mechanism of high dose tolerance [J].

Michallet, MC ;

Saltel, F ;

Flacher, M ;

Revillard, JP ;

Genestier, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (09) :5405-5414

[87] Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases [J].

Mihelic, Marko ;

Teuscher, Cory ;

Turk, Vito ;

Turk, Dusan .

FEBS LETTERS, 2006, 580 (17) :4195-4199

[88] Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing [J].

Moss, CX ;

Villadangos, JA ;

Watts, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (12) :3442-3451

[89] Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor [J].

Ni, J ;

Fernandez, MA ;

Danielsson, L ;

Chillakuru, RA ;

Zhang, JL ;

Grubb, A ;

Su, J ;

Gentz, R ;

Abrahamson, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24797-24804

[90] The cytoplasmic tail of invariant chain regulates endosome fusion and morphology [J].

Nordeng, TW ;

Gregers, TF ;

Kongsvik, TL ;

Méresse, S ;

Gorvel, JP ;

Jourdan, F ;

Motta, A ;

Bakke, O .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (06) :1846-1856

← 4 5 6 7 8 9 10 11 12 13 →