New vistas on macrophage differentiation and activation

被引：312

作者：

Mantovani, Alberto

Sica, Antonio

Locati, Massimo

机构：

[1] Ist Clin Humanitas, I-20089 Milan, Italy

[2] Univ Milan, Inst Gen Pathol, Milan, Italy

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2007年 / 37卷 / 01期

关键词：

cellular activation; innate immunity; macrophages; polarization;

D O I：

10.1002/eji.200636910

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasticity and heterogeneity are hallmarks of myelomonocytic differentiation and polarized activation. Evidence published in this issue of the European Journal of Immunology, together with other recent data, add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and activation and are discussed in this Commentary.

引用

页码：14 / 16

页数：3

共 23 条

[1] A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-κB and enhanced IRF-3/STAT1 activation)
Biswas, SK
Gangi, L
Paul, S
Schioppa, T
Saccani, A
Sironi, M
Bottazzi, B
Doni, A
Vincenzo, B
Pasqualini, F
Vago, L
Nebuloni, M
Mantovani, A
Sica, A
[J]. BLOOD, 2006, 107 (05) : 2112 - 2122
[2] Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages
Desnues, B
Lepidi, H
Raoult, D
Mege, JL
[J]. JOURNAL OF INFECTIOUS DISEASES, 2005, 192 (09) : 1642 - 1646
[3] Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Gallina, Giovanna
Dolcetti, Luigi
Serafini, Paolo
De Santo, Carmela
Marigo, Ilaria
Colombo, Mario P.
Basso, Giuseppe
Brombacher, Frank
Borrello, Ivan
Zanovello, Paola
Bicciato, Silvio
Bronte, Vincenzo
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (10) : 2777 - 2790
[4] Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages
Gawa, Kenji
Funaba, Masayuki
Chen, Yan
Tsujimoto, Masafumi
[J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (10) : 6787 - 6794
[5] Identification of a common gene signature for type H cytokine-associated myeloid cells elicited in vivo in different pathologic conditions
Ghassabeh, Gholamreza Hassanzadeh
De Baetselier, Patrick
Brys, Lea
Noel, Wim
Van Ginderachter, Jo A.
Meerschaut, Sofie
Beschin, Alain
Brombacher, Frank
Raes, Geert
[J]. BLOOD, 2006, 108 (02) : 575 - 583
[6] Monocyte and macrophage heterogeneity
Gordon, S
Taylor, PR
[J]. NATURE REVIEWS IMMUNOLOGY, 2005, 5 (12) : 953 - 964
[7] Alternative activation of macrophages
Gordon, S
[J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) : 23 - 35
[8] Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules
Helming, Laura
Gordon, Siamon
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (01) : 33 - 42
[9] Novel function of alternatively activated macrophages: Stabilin-1-mediated clearance of SPARC
Kzhyshkowska, Julia
Workman, Gail
Cardo-Vila, Marina
Arap, Wadih
Pasqualini, Renata
Gratchev, Alexei
Krtisell, Liis
Goerdt, Sergij
Sage, E. Helene
[J]. JOURNAL OF IMMUNOLOGY, 2006, 176 (10) : 5825 - 5832
[10] Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells
Lemaire, Irma
Falzoni, Simonetta
Leduc, Natacha
Zhang, Bin
Pellegatti, Patrizia
Adinolfi, Elena
Chiozzi, Paola
Di Virgilio, Francesco
[J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (10) : 7257 - 7265

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