Antioxidative action of diterpenoids from Podocarpus nagi

被引：62

作者：

Haraguchi, H ^{[1
]}

Ishikawa, H ^{[1
]}

Kubo, I ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT ENVIRONM SCI POLICY & MANAGEMENT,BERKELEY,CA 94720

来源：

PLANTA MEDICA | 1997年 / 63卷 / 03期

关键词：

Podocarpus nagi; podocarpaceae; totarol; totarane diterpenes; lipid peroxidation; mitochondrial oxidative injury;

D O I：

10.1055/s-2006-957655

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Diterpenoids, totarol (1), totaradiol (2), 19-hydroxytotarol (3), totaral (4), 4 beta-carboxy-19-nortotarol (5), sugiol (6), isolated from Podocarpus nagi, were evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/NADH were inhibited by these terpenoids. They inhibited linoleic acid autoxidation but not generation of superoxide anion. Totarol (1) protected mitochondrial respiratory enzyme activities against NADPH induced oxidative injury. Totarane diterpenes from P. nagi were shown to be effective to protect biological systems and function against various oxidative stresses.

引用

页码：213 / 215

页数：3

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