Human MutLα:: The jack of all trades in MMR is also an endonuclease

被引：20

作者：

Yang, Wei ^{[1
]}

机构：

[1] NIDDKD, NIH, Mol Biol Lab, Bethesda, MD 20892 USA

来源：

DNA REPAIR | 2007年 / 6卷 / 01期

关键词：

mismatch repair (MMR); endonuclease activity; regulation; strand specificity; ATPase; DNA binding; divalent cation;

D O I：

10.1016/j.dnarep.2006.10.021

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recently, Paul Modrich's group reported the discovery of an intrinsic endonuclease activity for human MutL alpha. This breakthrough provides a satisfactory answer to the longstanding puzzle of a missing nuclease activity in human mismatch repair and will undoubtedly lead to new investigations of DNA repair and replication. Here, the implications of this exciting new finding are discussed in the context of mismatch repair in Escherichia coli and humans. (c) 2006 Elsevier B.V. All rights reserved.

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页码：135 / 139

页数：5

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