A disposable lab-on-a-chip platform with embedded fluid actuators for active nanoliter liquid handling

被引：32

作者：

Samel, Bjorn ^{[1
]}

Nock, Volker ^{[1
]}

Russom, Aman ^{[1
]}

Griss, Patrick ^{[1
]}

Stemme, Goran ^{[1
]}

机构：

[1] Royal Inst Technol, Sch Elect Engn, Microsyst Technol Lab, Stockholm, Sweden

来源：

BIOMEDICAL MICRODEVICES | 2007年 / 9卷 / 01期

关键词：

lab-on-a-chip; microfluidics; micropump; PDMS composite; biochip;

D O I：

10.1007/s10544-006-9015-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this work we present the development of a disposable liquid handling lab-on-a-chip (LOC) platform with embedded actuators for applications in analytical chemistry. The proposed platform for nanoliter liquid handling is based on a thermally responsive silicone elastomer composite, consisting of PDMS and expandable microspheres. In our LOC platform, we integrate active dosing, transportation and merging of nanoliter liquid volumes. The disposable platform successfully demonstrates precise sample volume control with smart microfluidic manipulation and on-chip active microfluidic components. It is entirely fabricated from low-cost materials using wafer-level processing. Moreover, an enzymatic reaction and real-time detection was successfully conducted to exemplify its applicability as an LOC.

引用

页码：61 / 67

页数：7

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