Nature meets nurture: molecular genetics of gastric cancer

被引：177

作者：

Milne, Anya N. ^{[1
]}

Carneiro, F. ^{[2
,3
]}

O'Morain, C. ^{[4
]}

Offerhaus, G. J. A. ^{[1
,5
]}

机构：

[1] Univ Med Ctr Utrecht, Pathol Dept H04 2 25, NL-3508 GA Utrecht, Netherlands

[2] Univ Porto, Inst Mol Pathol & Immunol, IPATIMUP, P-4100 Oporto, Portugal

[3] Hosp Sao Joao, Fac Med, Oporto, Portugal

[4] Adelaide & Meath Hosp, Dept Gastroenterol, Dublin, Ireland

[5] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

来源：

HUMAN GENETICS | 2009年 / 126卷 / 05期

关键词：

HELICOBACTER-PYLORI-INFECTION; INDEPENDENT PROGNOSTIC-FACTOR; CADHERIN GERMLINE MUTATIONS; CHRONIC ATROPHIC GASTRITIS; NECROSIS-FACTOR-ALPHA; MICROSATELLITE INSTABILITY; INTESTINAL METAPLASIA; EARLY-ONSET; STEM-CELLS; SONIC HEDGEHOG;

D O I：

10.1007/s00439-009-0722-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming and the relevant importance of some of these molecules is too often unclear. This review serves to bring us up-to-date with the latest findings as well as to look at the larger picture in terms of how to tackle the problem of solving this multi-piece puzzle. In this review, the environmental nurturing of intestinal cancer is discussed, beginning with epidemiology (known causative factors for inducing molecular change), an update of H. pylori research, including the role of inflammation and stem cells in premalignant lesions. The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed.

引用

页码：615 / 628

页数：14

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